HCG 5000 IU

What is HCG 5000 IU?

HCG 5000 IU is a single vial of human chorionic gonadotropin containing 5,000 international units of lyophilised (freeze-dried) powder, supplied for research use. hCG is a glycoprotein hormone of 237 amino acids and roughly 36.7 kDa, built from two subunits: an alpha subunit of 92 amino acids that it shares with luteinising hormone, FSH and TSH, and a beta subunit of 145 amino acids that is unique to hCG.

That beta subunit carries a carboxy-terminal peptide extension, and it is the reason hCG behaves so differently from the hormone it imitates. Luteinising hormone is cleared from the blood in a couple of hours. hCG, carrying the same message to the same receptor, lasts more than a day.

How hCG works in men

hCG is a luteinising hormone analogue. It binds the LHCG receptor — the same receptor LH uses — and in men that receptor sits on the Leydig cells of the testes. Stimulating it makes the testes produce testosterone directly, which is why hCG raises intratesticular testosterone rather than simply adding hormone to the bloodstream from outside.

That distinction is the whole point. Intratesticular testosterone is what the Sertoli cells need to support spermatogenesis, and it is what keeps testicular tissue from shrinking. Injected testosterone raises serum levels but shuts down the signal from the brain, so the testes go quiet and, over months, lose volume. hCG substitutes for that missing signal at the testicular end.

What it does not do is restore the signal itself. hCG replaces LH; it does not persuade the pituitary to start making LH again. That single fact is behind the most common misunderstanding about this compound, covered further down.

Product details

• Compound: Human chorionic gonadotropin (hCG)
• Presentation: 5,000 IU lyophilised powder, 1 vial
• Form: Freeze-dried powder requiring reconstitution before use
• Diluent: Not included — bacteriostatic water is the usual choice
• Category: Peptides
• Shipping: US domestic, USPS Priority, 3–5 business days

Half-life and timing

hCG has an unusually long half-life for a peptide hormone. Published pharmacokinetic work puts the mean terminal elimination half-life at roughly 29 hours, with a reported range of about 23 to 35 hours, and studies of the conventional formulation commonly cite 32 to 33 hours. Serum levels are detectable within about 2 hours of an intramuscular injection, peak around 6 hours, and remain measurably elevated for roughly 36 hours.

Subcutaneous and intramuscular administration produce similar bioavailability; the published comparisons find no meaningful pharmacokinetic difference between the two routes, which is why subcutaneous dosing is common in practice despite older labelling specifying intramuscular.

The practical consequence of a ~30-hour half-life is that hCG does not need daily administration to maintain a signal. Clinical protocols for male hypogonadotropic hypogonadism generally describe two or three injections per week rather than daily ones.

Reconstitution and storage

The vial arrives as dry powder and has to be reconstituted. The powder itself is stable and tolerates shipping; once it is in solution, it needs refrigeration.

The arithmetic is where most mistakes happen, because the same vial can be made into wildly different concentrations depending on how much water goes in. With a standard U-100 insulin syringe, 10 units on the barrel equals 0.1 mL. For a 5,000 IU vial:

• 1 mL bacteriostatic water → 5,000 IU/mL → 10 units on the syringe = 500 IU
• 2 mL bacteriostatic water → 2,500 IU/mL → 10 units = 250 IU
• 5 mL bacteriostatic water → 1,000 IU/mL → 10 units = 100 IU

More diluent makes small doses easier to measure accurately, which is why larger volumes are common when the intended dose is a few hundred IU. Add the water slowly down the inside wall of the vial and swirl rather than shake — hCG is a protein and aggressive agitation can denature it.

Reconstituted with bacteriostatic water (which contains benzyl alcohol as a preservative) and kept refrigerated, hCG solution is generally considered usable for around 30 to 60 days. Sterile water, with no preservative, gives a far shorter window. Unopened powder stored cool and dark keeps far longer than the solution does.

Where hCG sits alongside testosterone

The common use is maintenance. Someone running testosterone enanthate, cypionate, propionate or Sustanon suppresses their own LH output, and the testes stop being asked to do anything. Adding hCG keeps the Leydig cells working through that period, which is why it is associated with preserved testicular volume and fertility markers during otherwise suppressive protocols.

It sits in a different category from the aromatase inhibitors and SERMs it is often listed beside. Arimidex and Aromasin reduce oestrogen conversion. Nolvadex, Clomid and enclomiphene act at the pituitary to restart LH and FSH output. hCG does neither — it bypasses the pituitary entirely and speaks directly to the testes. Browse the full ancillaries range for the compounds that work at the other end of the axis.

One further note: because hCG stimulates testosterone production, it also increases the substrate available for aromatisation. Oestrogen can rise on hCG, and it is worth knowing that before assuming a rising number came from somewhere else.

The misconception: hCG is not a substitute for post-cycle therapy

hCG is routinely described as a PCT drug. Mechanistically that does not hold together, and it is worth being clear about why.

The goal of post-cycle therapy is to get the body’s own hormonal axis running again — hypothalamus releasing GnRH, pituitary releasing LH and FSH, testes responding. hCG is exogenous LH activity. It makes the testes work, but as far as the pituitary is concerned the loop is still being satisfied from outside, so there is no signal to resume its own production. Run on its own after a cycle, hCG can prolong exactly the shutdown it is supposed to resolve, and high sustained doses have been associated with Leydig cell desensitisation.

Where hCG genuinely earns its place is before that point — keeping testicular tissue responsive during a suppressive period, so that when the SERMs go in there is something ready to respond. The recovery itself is the SERM’s job.

hCG and fat loss: what the evidence actually says

hCG has been marketed for weight loss for decades, and the claim does not survive contact with the evidence. There is no scientific support for hCG as a treatment for obesity. In December 2011 the FDA acted against over-the-counter hCG weight-loss products as fraudulent.

The reason the “hCG diet” appears to work is that it is built around a 500 to 1,000 calorie-per-day intake. Anyone eating 500 calories a day will lose weight, with or without an injection. Controlled comparisons of hCG against placebo, with the same caloric restriction on both sides, do not show hCG contributing anything.

We would rather say that plainly than sell a vial on a claim that is not true. If metabolic and body-composition research is the actual interest, the GLP-1 and dual-agonist compounds and triple agonists are the class with real published data behind them — hCG is not, and never was, a fat-loss drug.

Two things people are caught out by

It will produce a positive pregnancy test. Over-the-counter pregnancy tests detect hCG — that is the entire mechanism. A man with hCG in his system will test positive on one. It is a well-documented curiosity rather than a problem, but it surprises people.

It is detectable and it is banned. hCG is on the WADA prohibited list for male athletes and is screened for in drug-tested sport; positive tests have ended seasons for professional athletes in both baseball and football. Anyone subject to testing should treat hCG as a compound that will be found, not one that hides. The same applies to nandrolone and trenbolone for different reasons.

HCG 5000 IU or 10000 IU?

The hormone is identical; only the quantity in the vial differs. The 5,000 IU vial is the sensible default for a shorter protocol or a first purchase, because once reconstituted the solution is on a clock and unused hormone in the fridge is wasted money. If the intended use runs longer, the HCG 10000 IU vial works out meaningfully cheaper per IU — that page covers the arithmetic.

Where to buy HCG 5000 IU online in the US

KGEAR U.S ships HCG 5000 IU domestically inside the United States. Nothing crosses a border, so there is no customs step and no international delay — the practical reason most buyers looking for HCG 5000 IU for sale end up filtering for a US domestic source in the first place.

Shipping is a $30 flat rate, USPS Priority, US domestic only, normally 3–5 business days. Orders over $400 ship free. Every order needs at least 2 items and a $100 subtotal (two of the same item counts). Checkout is Bitcoin — if you have not used it before, the step-by-step guide takes about ten minutes. Questions go to Signal @kgearadmin2.25 and usually get answered the same day.

You can also browse the wider peptides range, including HGH and IGF-1 LR3.

HCG 5000 IU FAQ

What does HCG 5000 IU mean?
It means the vial contains 5,000 international units of human chorionic gonadotropin as dry powder. IU is a measure of biological activity rather than weight, which is the convention for this hormone.

Does HCG 5000 IU come with bacteriostatic water?
No. The vial contains lyophilised powder only. Bacteriostatic water is bought separately and is the usual diluent because its preservative gives the reconstituted solution a useful shelf life.

How long does hCG last once mixed?
Reconstituted with bacteriostatic water and kept refrigerated, roughly 30 to 60 days is the commonly cited window. With plain sterile water it is far shorter, because there is nothing preventing bacterial growth.

How long does hCG stay in your system?
The terminal half-life is about 29 hours, with peak levels around 6 hours after injection and measurable levels for roughly 36 hours. Full clearance takes several days.

Is hCG the same as HGH?
No. They are unrelated hormones with different receptors and different effects. hCG mimics luteinising hormone and acts on the testes; HGH is somatotropin and acts through IGF-1. The similar abbreviations cause a lot of confusion.

Can hCG be injected subcutaneously?
Published comparisons show similar bioavailability between subcutaneous and intramuscular administration, with no meaningful pharmacokinetic difference between the routes.

Will hCG restart my natural testosterone after a cycle?
Not on its own. hCG acts on the testes, not the pituitary, so it does not prompt the body to resume its own LH production. That is what SERMs such as Nolvadex, Clomid and enclomiphene are used for.

How do I buy HCG 5000 IU from KGEAR U.S?
Orders need at least 2 items and a $100 subtotal — two of the same vial counts — and are paid in Bitcoin at checkout. Shipping is $30 flat and US domestic, free over $400, normally arriving in 3–5 business days.

Important information

This product is sold for research and laboratory use. Nothing on this page is medical advice, a prescription, or a recommendation to use hCG. Human chorionic gonadotropin is a prescription medicine in the United States and its use outside a doctor’s care carries real risks. The dosing figures quoted here describe what appears in published clinical literature and product labelling; they are reference information, not instructions. hCG is a prohibited substance in male athletes under the WADA code. Speak to a qualified physician before beginning, changing, or stopping any hormone protocol.